Dr. Szűcs Attila, PhD
senior research fellow
Teaching activity (in English)
- Methods in Neurophysioogy Pr
- Electrophysiology L, Pr
Activity-dependent plasticity in biophysical and physiological properties of developing neurons. In this research, we investigate the effects of deprivation or other manipulation of electrical activity in primary hippocampal neuronal cultures and organotopic slice cultures. Our research focuses on the homeostatic regulation of neural networks, and we have characterized the role of nonspecific cationic currents and T-type Ca currents in these processes.
Electrophysiological analysis and manipulation of human neurons obtained by genetic reprogramming using optogenetic methods. The study of neurons derived from human somatic cells by genetic reprogramming represents an extremely important research direction in contemporary brain research. Our novel method is to control these developing neuron populations by time-structured, long-term optogenetic stimulation and to analyse in detail the physiological, neurochemical and biophysical properties of the "trained" neurons.
Development and application of hybrid technologies in biological neuron networks. One of the strengths of our research group is the ability to apply the dynamic clamp method at the mega-scale. Using this method, we can generate computer-simulated voltage-dependent and/or synaptic conductances in biological neurons to study their effects on the dynamic function and signal processing capacity of the cells.